Vol. 5 No. 3 (2026): EIYB (Educational Yield Insights & Breakthroughs)
Articles

ONKOGENEZDA GORMONLARNING RO’LI VA GORMONGA BOG‘LIQ O‘SMALAR.

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  • Axmedova Surayyo Nurali qizi,
  • Axmatova Dilnura Akromjon qizi,
  • Qutbiyeva Nargiza Zikriddin qizi,
  • Xamidullayeva Sarvinoz O‘tkir qizi
Axmedova Surayyo Nurali qizi
Toshkent Davlat Tibbiyot Universiteti, 1-son Tibbiy va biologik kimyo kafedrasi assistenti.
Axmatova Dilnura Akromjon qizi
Toshkent Davlat Tibbiyot Universiteti, 2-son Davolash ishi fakulteti talabasi, Toshkent, O‘zbekiston
Qutbiyeva Nargiza Zikriddin qizi
Toshkent Davlat Tibbiyot Universiteti, 2-son Davolash ishi fakulteti talabasi, Toshkent, O‘zbekiston
Xamidullayeva Sarvinoz O‘tkir qizi
Toshkent Davlat Tibbiyot Universiteti, 2-son Davolash ishi fakulteti talabasi, Toshkent, O‘zbekiston

Published 2026-05-12

Keywords

  • Onkogenez, gormonga bog‘liq o‘smalar, estrogen, androgenlar, sut bezi saratoni, prostat bezi saratoni, tuxumdon saratoni, retseptorlar, gormonal disbalans.

Abstract

Ushbu maqolada onkogenez jarayonida gormonlarning roli va gormonga bog‘liq o‘smalarning zamonaviy onkologiyadagi ahamiyati yoritilgan. Maqolada sut bezi, prostat bezi, tuxumdon, endometriy, qalqonsimon bez hamda oshqozon osti bezi saratonlari misolida gormonal disbalansning o‘sma rivojlanishidagi molekulyar mexanizmlari tahlil qilingan. Xususan, estrogen, progesteron, androgenlar, insulin va qalqonsimon bez gormonlarining hujayra proliferatsiyasi, apoptoz inhibisiyasi, genom beqarorligi va onkogenlarning faollashuviga ta’siri batafsil ko‘rib chiqilgan. Shuningdek, maqolada global statistik ma’lumotlar (2024–2026) asosida gormonga bog‘liq o‘smalarning kasallanish va o‘lim ko‘rsatkichlari, ularning yosh va jinsga oid xususiyatlari, shuningdek depressiv buzilish bilan komorbidlik holatlari tahlil etilgan.

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