ORGAN TO‘QIMALARIDA METABOLIK FERMENTLAR FAOLIYATI VA ULARNING GISTOLOGIK LOKALIZATSIYASI
Keywords:
Ushbu tahliliy maqolada metabolik fermentlarning organ to‘qimalarida faollanish mexanizmlari, ularning gistologik lokalizatsiyasi va hujayra darajasidagi funksional taqsimlanishi zamonaviy biokimyoviy va gistotexnik usullar asosida ko‘rib chiqildi. Tadqiqotlarda oksidlovchi–qaytaruvchi fermentlar (degidrogenazalar), lizosomal gidrolazalar, oksidaza-komplekslar va Na⁺/K⁺-ATFaza kabi membrana fermentlarining faoliyatiga alohida e’tibor qaratildi. Immunogistokimyo, sitoximiya va spektrofotometrik analizlar asosida fermentlarning turli organlarda differensial taqsimlanishi, shuningdek, metabolik stress, gipoksiya va yallig‘lanish sharoitida ularning ekspressiya darajalaridagi o‘zgarishlar haqida ilmiy ma’lumotlar umumlashtirildi. Natijalar shuni ko‘rsatadiki, organ-spesifik ferment profillari fiziologik jarayonlarning nozik regulyatsiyasida markaziy rol o‘ynaydi.Abstract
Ushbu tahliliy maqolada metabolik fermentlarning organ to‘qimalarida faollanish mexanizmlari, ularning gistologik lokalizatsiyasi va hujayra darajasidagi funksional taqsimlanishi zamonaviy biokimyoviy va gistotexnik usullar asosida ko‘rib chiqildi. Tadqiqotlarda oksidlovchi–qaytaruvchi fermentlar (degidrogenazalar), lizosomal gidrolazalar, oksidaza-komplekslar va Na⁺/K⁺-ATFaza kabi membrana fermentlarining faoliyatiga alohida e’tibor qaratildi. Immunogistokimyo, sitoximiya va spektrofotometrik analizlar asosida fermentlarning turli organlarda differensial taqsimlanishi, shuningdek, metabolik stress, gipoksiya va yallig‘lanish sharoitida ularning ekspressiya darajalaridagi o‘zgarishlar haqida ilmiy ma’lumotlar umumlashtirildi. Natijalar shuni ko‘rsatadiki, organ-spesifik ferment profillari fiziologik jarayonlarning nozik regulyatsiyasida markaziy rol o‘ynaydi.
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